Avaliação
David Rodrigues da Rocha
David Rodrigues da Rocha
Bolsista de Produtividade em Pesquisa CIENTISTA DO NOSSO ESTADO – FAPERJ
CNPq-Nível 2
CNPq-Nível 2
Áreas de Interesse:
(1) Reações catalisadas por micro-ondas (2) Síntese e avaliação biológica de naftoquinonas e heterociclos (3) Uso de carboidratos em síntese orgânica
Resumo
Possui graduação em Farmácia Industrial pela Universidade Federal Fluminense (2005), mestrado em Química Orgânica (2006) e doutorado em Química Orgânica pela Universidade Federal Fluminense (2010). Foi Jovem Cientista do nosso Estado (FAPERJ) de 2018-2024, Secretário Regional da Sociedade Brasileira de Química - RJ (2016-2018), Vice-Secretário Regional da Sociedade Brasileira de Química - RJ (2018-2020 e 2020-2022), Editor Chefe da Revista Virtual de Química (2018-2024), Vice-Coordenador do Programa de Pós-Graduação em Química da Universidade Federal Fluminense (2017-2019) e Coordenador do Programa de Pós-Graduação em Química da Universidade Federal Fluminense (2019-2023) . Atualmente é Professor Associado IV da Universidade Federal Fluminense, Coordenador do Laboratório de Síntese de Moléculas de Interesse Biológico (SiMIB), Membro da coordenação do Exame Unificado de Química (2024-2026), Cientista do nosso Estado (FAPERJ) desde 2024 e Vice-Diretor do Instituto de Química da Universidade Federal Fluminense (2023-2027). Associado efetivo da Sociedade Brasileira de Química. Tem experiência na área de Química, com ênfase em Síntese Orgânica, atuando principalmente nos seguintes temas: naftoquinonas, heterociclos, carboidratos, reações em micro-ondas, reações em alta pressão e diazocompostos.
Publicações
1. DOS SANTOS, VINICIUS M. ; SANTOS, THAIS B. ; FERNANDES, CAIO M. ; JUNIOR, HEBSON O. C. ; RIBEIRO, RAFAELLA M. A. C. ; Ferreira, Vitor F. ; LEE, HAN-SEUNG ; LGAZ, HASSANE ; da Rocha, David R. ; PONZIO, EDUARDO A. . Electrochemicaland Theoretical Evaluation of Carbothioamide-DerivedCorrosion Inhibitors for Mild Steel in Acidic Environments. LANGMUIR, v. 42, p. 22657-22677, 2026.
2. G. C. DE MORAES, LEONARDO ; B. GUIDINELE, MARIA CRISTINA ; F. FERREIRA, VITOR ; R. DA ROCHA, DAVID . One-Pot Sodium Azide-Free Synthesis of Aryl Azides from Anilines. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v. 36, p. e-20250002, 2025.
3. C. THURLER-JÚNIOR, JULIO ; S. MOREIRA, CAROLINE ; C. CASTIGLIONE, RAQUEL ; L. SIMÕES, RAFAEL ; G. G. RANDO, DANIELA ; F. T. R. MARTINS, FELIPE ; M. COGO, RAMON ; C. B. RIBEIRO, RUAN ; F. FERREIRA, VITOR ; D. B. PASCOAL, VINICIUS ; C. R. F. PASCOAL, AISLAN ; R. DA ROCHA, DAVID . Antiproliferative Activity of New Bis-Thionaphthoquinones in Cervical Cancer. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v. 36, p. e-20240207, 2025.
4. CESAR CIRNE-SANTOS, CLAUDIO ; GOMES GONZAGA, DANIEL TADEU ; OLIVEIRA DE RESENDE, GABRIEL ; GONÇALVES, MARIANA DE CASTRO ; ANDRADE, AYMEE DA SILVA ; FURTADO PACHECO, PAULO ANASTÁCIO ; DOS SANTOS-RODRIGUES, ALEXANDRE ; RABELO, VITOR WON-HELD ; ABREU, PAULA ALVAREZ ; FARIA, ROBSON XAVIER ; DA ROCHA, DAVID RODRIGUES ; DA SILVA, FERNANDO DE CARVALHO ; FERREIRA, VITOR FRANCISCO ; DE SOUZA BARROS, CAROLINE ; NUNES DE PALMER PAIXÃO, IZABEL CHRISTINA . PAV-05 Naphthoquinone Potently Inhibit Zika Virus Replication in Infected Cells. CURRENT TOPICS IN MEDICINAL CHEMISTRY, v. 25, p. 1733-1747, 2025.
5. GUERRA, FABIANA SÉLOS ; FREITAS, ROSANA HELENA COIMBRA NOGUEIRA DE ; MOLDOVAN, FLORINA ; ROCHA, DAVID RODRIGUES DA ; CARVALHO, RENATO SAMPAIO ; FERNANDES, PATRICIA DIAS . Design, Synthesis, and Bioactivity Assessment of Modified Vemurafenib Analog. PHARMACEUTICALS, v. 18, p. 1161, 2025.
6. SANTOS, THAÍS BARRETO ; DE SOUZA CRUZ LOPES CANUTO, ALEX ; MEIRA, JOÃO FRANCISCO BLAUDT VIRGILIO DE CARVALHO ; SANTOS-DINIZ, ANA CAROLINE ; RIBEIRO, RAFAELLA MACHADO DE ASSIS CABRAL ; PASCHOAL, CAROLINE REIS SANTIAGO ; RABELO, VITOR WON-HELD ; ABREU, PAULA ALVAREZ ; FERREIRA, VITOR FRANCISCO ; DA ROCHA, DAVID RODRIGUES ; ROBBS, BRUNO KAUFMANN . Mechanistic Insights into the Anticancer Action of Novel 2-Hydroxy-1,4-naphthoquinone Thiol Derivatives. ACS Omega, v. 10, p. 41975-41992, 2025. Citações:1|2
7. DE MORAES, LEONARDO GOMES CAVALIERI ; SANTOS, THAÍS BARRETO ; DA ROCHA, DAVID RODRIGUES . Molecular Hybridization of Naphthoquinones and Thiazoles: A Promising Strategy for Anticancer Drug Discovery. PHARMACEUTICALS, v. 18, p. 1887, 2025. Citações:1|2
8. G. C. DE MORAES, LEONARDO ; R. DA ROCHA, DAVID . Strategies for the Synthesis of Monohalogenated Analogues of Juglone: Unlocking the Potential of Regiospecific Synthesis Methodologies. REVISTA VIRTUAL DE QUÍMICA, v. 16, p. 127-137, 2024.
9. SILVA, STÉPHANE DA ; SILVA, EDUARDO MOREIRA DA ; CARVALHO, EDUARDA LIMA MUNIZ DE ; MOREIRA, CAROLINE DOS SANTOS ; DA ROCHA, DAVID RODRIGUES ; TURBINO, MIRIAM LACALLE ; PORTELA, MARISTELA BARBOSA ; AMARAL, CRISTIANE MARIOTE . Effect of dentin pretreatment with dialdehyde carboxymethyl cellulose on dentin properties and long-term adhesion. INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES, v. 120, p. 103296, 2023. Citações:4|4
10. PACHECO, PAULO ANASTÁCIO FURTADO ; GONZAGA, DANIEL TADEU GOMES ; VON RANKE, NATALIA LIDMAR ; RODRIGUES, CARLOS RANGEL ; DA ROCHA, DAVID RODRIGUES ; DA SILVA, FERNANDO DE CARVALHO ; FERREIRA, VITOR FRANCISCO ; FARIA, ROBSON XAVIER . Synthesis, Biological Evaluation and Molecular Modeling Studies of Naphthoquinone Sulfonamides and Sulfonate Ester Derivatives as P2X7 Inhibitors. MOLECULES, v. 28, p. 590, 2023. Citações:2|2
11. PACHECO, PAULO ANASTÁCIO FURTADO ; FARIA, JULIANA VIEIRA ; SILVA, ANA CLÁUDIA ; VON RANKE, NATALIA LIDMAR ; SILVA, ROBSON COUTINHO ; RODRIGUES, CARLOS RANGEL ; DA ROCHA, DAVID RODRIGUES ; FARIA, ROBSON XAVIER . In silico and pharmacological study of N,S-acetal juglone derivatives as inhibitors of the P2X7 receptor-promoted in vitro and in vivo inflammatory response. BIOMEDICINE & PHARMACOTHERAPY, v. 162, p. 114608, 2023. Citações:2|3
12. SANTOS, THAÍS BARRETO ; DE MORAES, LEONARDO GOMES CAVALIERI ; PACHECO, PAULO ANASTÁCIO FURTADO ; DOS SANTOS, DOUGLAS GALDINO ; RIBEIRO, RAFAELLA MACHADO DE ASSIS CABRAL ; MOREIRA, CAROLINE DOS SANTOS ; DA ROCHA, DAVID RODRIGUES . Naphthoquinones as a Promising Class of Compounds for Facing the Challenge of Parkinson’s Disease. PHARMACEUTICALS, v. 16, p. 1577, 2023. Citações:9|6
13. PACHECO, PAULO ; GONZAGA, DANIEL ; CIRNE-SANTOS, CLÁUDIO ; BARROS, CAROLINE ; GOMES, MAX ; GOMES, RAFAELA ; GONÇALVES, MARIANA ; FERREIRA, VITOR ; RABELO, VITOR ; ABREU, PAULA ; FARIA, ROBSON ; DE RESENDE, GABRIEL ; Da Rocha, David ; PAIXÃO, IZABEL ; DA SILVA, FERNANDO . Synthesis and Anti-Chikungunya Virus (CHIKV) Activity of Novel 1,4-Naphthoquinone Sulfonamide and Sulfonate Ester Derivatives. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v. 33, p. 556-569, 2022. Citações:11|11
14. GUILHON'SIMPLICIO, FERNANDA ; SERRÃO, CARLOS KLINGER RODRIGUES ; PINTO, ANA CRISTINA DA SILVA ; PACHECO, PAULO ANASTÁCIO FURTADO ; FARIA, ROBSON XAVIER ; ROCHA, DAVID RODRIGUES ; FERREIRA, VITOR FRANCISCO ; PEREIRA'JUNIOR, RAIMUNDO CARLOS ; MATHEEUSSEN, AN ; BAÁN, ADRIENN ; KIEKENS, FILIP ; MENESES PEREIRA, MARIA ; LIMA, EMERSON SILVA ; WINTER, HANS DE ; COS, PAUL . Semisynthetic triterpenes led to the generation of selective antitrypanosomal lead compounds. Chemical Biology & Drug Design, v. 99, p. 868-883, 2022. Citações:3|3
15. DE SOUSA PORTILHO, ADRHYANN JULLYANNE ; DA SILVA, EMERSON LUCENA ; BEZERRA, EMANUEL CINTRA AUSTREGÉSILO ; MORAES REGO GOMES, CARINNE BORGES DE SOUZA ; FERREIRA, VITOR ; DE MORAES, MARIA ELISABETE AMARAL ; DA ROCHA, DAVID RODRIGUES ; BURBANO, ROMMEL MÁRIO RODRIGUEZ ; MOREIRA-NUNES, CAROLINE AQUINO ; MONTENEGRO, RAQUEL CARVALHO . 1,4-Naphthoquinone (CNN1) Induces Apoptosis through DNA Damage and Promotes Upregulation of H2AFX in Leukemia Multidrug Resistant Cell Line. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, p. 8105, 2022. Citações:15|13
16. DOS SANTOS, JULIANA P. S. ; RIBEIRO, RUAN CARLOS B. ; FARIA, JULIANA V. ; BELLO, MURILO L. ; LIMA, CAROLINA G. S. ; PAULI, FERNANDA P. ; BORGES, AMANDA A. ; ROCHA, DAVID R. ; MORAES, MATHEUS G. ; FOREZI, LUANA S. M. ; Ferreira, Vitor F. ; FARIA, ROBSON X. ; DA SILVA, FERNANDO DE C. . Synthesis, biological evaluation and molecular modeling studies of novel 1,2,3-triazole-linked menadione-furan derivatives as P2X7 inhibitors. Journal of Bioenergetics and Biomembranes, v. 54, p. 227-239, 2022. Citações:10|10
17. DA SILVA, EMERSON LUCENA ; MESQUITA, FELIPE PANTOJA ; DE FARIAS RAMOS, INGRYD NAYARA ; DE SOUZA MORAES REGO GOMES, CARINNE BORGES ; DOS SANTOS MOREIRA, CAROLINE ; FERREIRA, VÍTOR FRANCISCO ; DA ROCHA, DAVID RODRIGUES ; DE OLIVEIRA BAHIA, MARCELO ; MOREIRA-NUNES, CAROLINE AQUINO ; DE SOUZA, CAROLINA ROSAL TEIXEIRA ; BURBANO, ROMMEL MARIO RODRIGUES ; MONTENEGRO, RAQUEL CARVALHO . Antitumoral effect of novel synthetic 8-hydroxy-2-((4-nitrophenyl)thio)naphthalene-1,4-dione (CNN16) via ROS-mediated DNA damage, apoptosis and anti-migratory effect in colon cancer cell line. TOXICOLOGY AND APPLIED PHARMACOLOGY, v. 456, p. 116256, 2022. Citações:8|8
18. DA SILVA MAGALHÃES FOREZI, LUANA ; GARCIA FERREIRA, PATRÍCIA ; Rodrigues da Rocha, David ; de Carvalho da Silva, Fernando ; FRANCISCO FERREIRA, VITOR . There is Chemistry Here: Supermarket. Part III: Carbohydrates. REVISTA VIRTUAL DE QUÍMICA, v. 14, p. 745-766, 2022.
19. LARA, LEONARDO S. ; LECHUGA, GUILHERME C. ; MOREIRA, CAROLINE DOS S. ; SANTOS, THAÍS B. ; Ferreira, Vitor F. ; da Rocha, David R.; PEREIRA, MIRIAN C. S. . Optimization of 1,4-Naphthoquinone Hit Compound: A Computational, Phenotypic, and In Vivo Screening against Trypanosoma cruzi. MOLECULES, v. 26, p. 423, 2021. Citações:15|14
20. FREITAS, ROSANA HELENA C. N. ; Rodrigues da Rocha, David . 4-(Dimethylamino)pyridine as Multivalent Catalyst in Organic Synthesis. AUSTRALIAN JOURNAL OF CHEMISTRY, v. 74, p. 364-366, 2021. Citações:2|2
21. Ferreira, Vitor F. ; DE CARVALHO, ALCIONE S. ; da Rocha, David R. . Strategies for the Synthesis of Mono- and Bis-Thionaphthoquinones. CURRENT ORGANIC SYNTHESIS, v. 18, p. 535-546, 2021. Citações:2|2
22. DE FREITAS, PAULA PRISCILLA ; RIBEIRO, RUAN CARLOS BUSQUET ; DOS SANTOS GUIMARÃES, ISABELLA ; MOREIRA, CAROLINE S. ; da Rocha, D. R. ; de Carvalho da Silva, Fernando ; FERREIRA, V. F. ; GIMBA, ETEL RODRIGUES PEREIRA . (3,3?-Methylene)bis-2-hydroxy-1,4-naphthoquinones induce cytotoxicity against DU145 and PC3 cancer cells by inhibiting cell viability and promoting cell cycle arrest. MOLECULAR BIOLOGY REPORTS, v. 48, p. 3253-3263, 2021. Citações:5|5
23. Moreira, C. S. ; SANTOS, T. B. ; FREITAS, ROSANA HELENA C. N. ; PACHECO, P. A. F. ; DA ROCHA, D.R. . Juglone: a versatile natural platform for obtaining new bioactive compounds. CURRENT TOPICS IN MEDICINAL CHEMISTRY, v. 21, p. 2018-2045, 2021. Citações:23|32
24. DE S. PORTILHO, ADRHYANN J. ; B. S. M. R. GOMES, CARINNE ; MOREIRA, CAROLINE S. ; DA S. M. FOREZI, LUANA ; CORDEIRO, PÂMELLA S. ; DO NASCIMENTO, VANESSA ; DANIEL, JULIO P. ; VASCONCELLOS, MARNE C. ; E. A. DE MORAES, MARIA ; DE F. A. MOREIRA-NUNES, CAROLINE ; Ferreira, Vitor F. ; MONTENEGRO, RAQUEL C. ; da Rocha, David R. . Synthesis, molecular docking, and biological activity of thioether derived from juglone in preclinical models of chronic myeloid leukemia. Computational Toxicology, v. 20, p. 100197, 2021. Citações:7|6
25. RIBEIRO, RUAN CARLOS ; DE FREITAS, PAULA ; MOREIRA, CAROLINE ; DE MORAES, LEONARDO ; DE MORAES, MATHEUS ; DA SILVA, FERNANDO ; Rocha, David ; GIMBA, ETEL ; FERREIRA, VITOR . A New Strategy for the Synthesis of Nonsymmetrical 3,3?-(Aryl/alkyl- methylene) bis-2-hydroxy-1,4-naphthoquinones and Their Cytotoxic Effects in PC3 Prostate Cancer Cells. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v. 31, p. 288-297, 2020. Citações:8|9
26. PACHECO, PAULO ANASTÁCIO FURTADO ; DE MENEZES RIBEIRO, THAIS ; DOS SANTOS GALVÃO, RAÍSSA MARIA ; DOS SANTOS, ELDIO GONÇALVES ; FARIA, ANA FLÁVIA MARTINS ; VON RANKE, NATALIA LIDMAR ; BELLO, MURILO LAMIM ; RODRIGUES, CARLOS RANGEL ; FERREIRA, VITOR FRANCISCO ; SOUZA, ANDRÉ LUIS ALMEIDA ; DE JESÚS HARDOIM, DAIANA ; DA SILVA CALABRESE, KATIA ; FARIA, ROBSON XAVIER ; DA ROCHA, DAVID RODRIGUES . Synthesis of new N,S-acetal analogs derived from juglone with cytotoxic activity against Trypanossoma cruzi. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, v. 52, p. 199-213, 2020. Citações:7|5
27. Rodrigues da Rocha, David; FRANCISCO FERREIRA, VITOR . Contributions of Chemistry to Low Contact Economy at the Time of COVID-19. REVISTA VIRTUAL DE QUÍMICA, v. 12, p. 1642-1652, 2020. Citações:2|2
28. Moreira, C. S. ; da Rocha, D. R. ; FARIAS, F. M. C. . Curso voluntário de atualização e aperfeiçoamento: Uma estratégia para o retorno dos jovens e adultos à sala de aula com ênfase no ensino CTS. Brazilian Journal of Development, v. 6, p. 100114-100125, 2020.
29. PACHECO, P.A.F. ; GALVÃO, R.M.S. ; FARIA, A.F.M. ; VON RANKE, N.L. ; RANGEL, M.S. ; RIBEIRO, T.M. ; BELLO, M.L. ; RODRIGUES, C.R. ; FERREIRA, V.F. ; DA ROCHA, D.R. ; FARIA, R.X. . 8-Hydroxy-2-(1H-1,2,3-triazol-1-yl)-1,4-naphtoquinone derivatives inhibited P2X7 Receptor-Induced dye uptake into murine Macrophages. BIOORGANIC & MEDICINAL CHEMISTRY, v. 27, p. 1449-1455, 2019. Citações:23|21
30. DE MELLO, MARCOS VINÍCIUS PALMEIRA ; CEBRIÁN-TORREJÓN, GERARDO ; PEREIRA, JONAS RAMOS ; DOS SANTOS MOREIRA, CAROLINE ; DE SOUZA MORAES REGO GOMES, CARINNE BORGES ; DA ROCHA, DAVID RODRIGUES ; DE SOUZA FAGUNDES, ELAINE MARIA; FERREIRA, GLAUCIO BRAGA ; LANZNASTER, MAURICIO . Evaluation of 5-hydroxy-1,4-naphthoquinone-cobalt(III) complexes for hypoxia-activated drug delivery. JOURNAL OF INORGANIC BIOCHEMISTRY, v. 199, p. 110756, 2019. Citações:10|12
31. MOREIRA, CAROLINE DOS S. ; NICOLETTI, CAROLINE D. ; PINHEIRO, DANIEL P. ; DE MORAES, LEONARDO G. C. ; FUTURO, DEBORA O. ; Ferreira, Vitor F. ; PESSOA, CLAUDIA DO Ó ; da Rocha, David R. . Synthesis of dehydro-?-lapachones, ?- and ?-lapachones, and screening against cancer cell lines. MEDICINAL CHEMISTRY RESEARCH, v. 28, p. 2109-2117, 2019. Citações:9|8
32. LARA, L.S. ; MOREIRA, C.S. ; CALVET, C.M. ; LECHUGA, G.C. ; SOUZA, R.S. ; BOURGUIGNON, S.C. ; FERREIRA, V.F. ; ROCHA, D. ; PEREIRA, M.C.S. . Efficacy of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinone derivatives against different Trypanosoma cruzi discrete type units: Identification of a promising hit compound. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 144, p. 572-581, 2018. Citações:41|40
33. NOVAIS, JULIANA S. ; MOREIRA, CAROLINE S. ; SILVA, ANA CAROLINA J.A. ; LOUREIRO, RAQUEL S. ; SÁ FIGUEIREDO, AGNES MARIE ; Ferreira, Vitor F. ; CASTRO, HELENA C. ; da Rocha, David R. . Antibacterial naphthoquinone derivatives targeting resistant strain Gram-negative bacteria in biofilms. MICROBIAL PATHOGENESIS, p. 105-114, 2018. Citações:49|52
34. WREDEN, ANNA BEATRIZ ; FERNANDES, LUIZA ; KELLEY, MIRIAN ; PEREIRA-NEVES, ANTÔNIO ; MOREIRA, CAROLINE S. ; da Rocha, David R. ; PALHANO, FERNANDO L . Selective and sensitive pull down of amyloid fibrils produced in vitro and in vivo by the use of pentameric-thiophene-coupled resins.. ACS Chemical Neuroscience, v. 9, p. 2807-2814, 2018. Citações:7|8
35. SODERO, A. C. R. ; ABRAHIM-VIEIRA, B. ; TORRES, P. H. M. ; PASCUTTI, P. G. ; GARCIA, CELIA RS ; FERREIRA, V. F. ; da Rocha, D. R. ; FERREIRA, S. B. ; Silva JR, F. P. . Insights into cytochrome bc1 complex binding mode of antimalarial 2-hydroxy-1,4-naphthoquinones through molecular modelling. Memórias do Instituto Oswaldo Cruz, v. 112, p. 299-308, 2017. Citações:15|18
36. CARDOSO, MARIANA F.C. ; Forezi, L. S. M. ; CAVALCANTE, V. G. S. ; JULIANI, C. S. R. ; Resende, J. A. L. C. ; da Rocha, D. R. ; da Silva, F. C. ; FERREIRA, V. F. . Synthesis of New Xanthenes Based on Lawsone and Coumarin via a Tandem Three-Component Reaction. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, p. 1926-1936, 2017. Citações:9|12
37. MOREIRA, C.S. ; SILVA, A.C.J.A. ; NOVAIS, J.S. ; SÁ FIGUEIREDO, A.M. ; FERREIRA, V.F. ; DA ROCHA, D.R. ; CASTRO, H.C. . Searching for a potential antibacterial lead structure against bacterial biofilms among new naphthoquinone compounds. Journal of Applied Microbiology (Print), v. 122, p. 651-662, 2017. Citações:33|33
38. CARDOSO, MARIANA ; GOMES, ANA ; MOREIRA, CAROLINE ; SIMÕES, MÁRIO ; NEVES, MARIA ; Da Rocha, David ; DA SILVA, FERNANDO ; MOREIRINHA, CATARINA ; ALMEIDA, ADELAIDE ; FERREIRA, VITOR ; CAVALEIRO, JOSÉ . Efficient Catalytic Oxidation of 3-Arylthio- and 3-Cyclohexylthio-lapachone Derivatives to New Sulfonyl Derivatives and Evaluation of Their Antibacterial Activities. Molecules (Basel. Online), v. 22, p. 302, 2017. Citações:10|10
39. LANZNASTER, MAURICIO ; DA SILVA, ALINE FARIAS MOREIRA ; VITAL, RENATA DE UZEDA ; MARTINS, DANIELA DE LUNA ; ROCHA, DAVID RODRIGUES ; FERREIRA, GLAUCIO BRAGA ; CAMARGOS-RESENDE, JACKSON A. L. . Investigation of cobalt(III)-tpa complexes as potential bioreductively activated carriers for naphthoquinone-based drugs. NEW JOURNAL OF CHEMISTRY, v. 41, p. 14960-14965, 2017. Citações:7|7
40. CARDOSO, MARIANA F.C. ; Salomão, K. ; BONBACA, A. C. ; da Rocha, D. R. ; da Silva, F. C. ; Cavaleiro, J. A. S. ; Castro, S. L. ; FERREIRA, V. F. . Synthesis and anti-Trypanosoma cruzi Activity of New 3¿Phenylthio-nor-?-lapachone Derivatives. Bioorganic & Medicinal Chemistry (Print), v. 23, p. 4763-4768, 2015. Citações:32|33
41. CAMPOS, VINICIUS R. ; CUNHA, ANNA C. ; SILVA, WANDERSON A. ; Ferreira, Vitor F. ; SANTOS DE SOUSA, CARLA ; FERNANDES, PATRÍCIA D. ; MOREIRA, VINÍCIUS N. ; da Rocha, David R. ; DIAS, FLAVIANA R. F. ; MONTENEGRO, RAQUEL C. ; DE SOUZA, MARIA C. B. V. ; BOECHAT, FERNANDA DA C. S. ; FRANCO, CAROLINE F. J. ; RESENDE, JACKSON A. L. C. . Synthesis of a new class of naphthoquinone glycoconjugates and evaluation of their potential as antitumoral agents. RSC Advances: an international journal to further the chemical sciences, v. 5, p. 96222-96229, 2015. Citações:24|24
42. FERREIRA, V. F. ; da Rocha, D. R. ; da Silva, F. C. . Green Chemistry, Sustainable Economy and Quality of Life. Revista Virtual de Química, v. 6, p. 85-111, 2014. Citações:16
43. da Rocha, D. R.; SILVA, K. M. ; SILVA, I. M. C. B. ; FERREIRA, V. F. ; FERREIRA, S. B. ; da Silva, F. C. . Synthesis of fused chromene-1,4-naphthoquinones via ring-closing metathesis and Knoevenagel-electrocyclization under acid catalysis and microwave irradiation. Tetrahedron (Oxford. Print), v. 70, p. 3266-3270, 2014. Citações:25|26
44. Rezende, C. M. ; da Silva, F. C. ; da Rocha, D. R. ; FERREIRA, V. F. . Piperylene Sulfone: A Smart Solvent. Revista Virtual de Química, v. 6, p. 131-141, 2014.
45. da Rocha, D. R.; Souza, A. M. T. ; de Souza, A. C. G. ; Castro, H. C. ; Rodrigues, C. R. ; Menna-Barreto, R. F. S. ; Castro, S. L. ; FERREIRA, V. F. . Effect of 9-hydroxy-a- and 7-hydroxy-pyran Naphthoquinones on Trypanosoma cruzi and Structure-activity Relationship Studies. Medicinal Chemistry, v. 10, p. 1-1, 2014. Citações:5|5
46. Pinto, E. G. ; SANTOS, I. O. ; Schmidt, T. J. ; Borborema, S. E. T. ; FERREIRA, V. F. ; da Rocha, D. R. ; Tempone, A. G. . Potential of 2-Hydroxy-3-Phenylsulfanylmethyl-[1,4]-Naphthoquinones against Leishmania (L.) infantum: Biological Activity and Structure-Activity Relationships. Plos One, v. 9, p. e105127, 2014. Citações:45|41
47. CARDOSO, MARIANA F.C. ; RODRIGUES, PATRÍCIA C. ; OLIVEIRA, MARIA EDUARDA I.M. ; GAMA, IVSON L. ; DA SILVA, ILLANA M.C.B. ; SANTOS, ISABELA O. ; ROCHA, DAVID R. ; PINHO, ROSA T. ; Ferreira, Vitor F. ; DE SOUZA, MARIA CECÍLIA B.V. ; DA SILVA, FERNANDO DE C. ; SILVA JUNIOR, FLORIANO PAES . Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines. European Journal of Medicinal Chemistry, v. 84, p. 708-717, 2014. Citações:53|54
48. Mariana F. C. Cardoso ; SILVA, I. M. C. B. ; SANTOS JUNIOR, H. M. ; da Rocha, David R. ; Ana Jérsia Araújo ; Pessoa, Cláudia ; Moraes, M. O. ; Costa-Lotufo, L. V. ; Fernando de Carvalho da Silva ; SANTOS, W. C. ; Vitor Francisco Ferreira . A new approach for the synthesis of 3-substituted cytotoxic nor-?-lapachones. Journal of the Brazilian Chemical Society (Impresso), v. 24, p. 12-16, 2013. Citações:21|18
49. Abhinay Sharma ; SANTOS, I. O. ; Pratibha Gaur ; Ferreira, Vitor F. ; Celia R.S Garcia ; da Rocha, David R. . Addition of thiols to o-quinone methide: New 2-hydroxy-3-phenylsulfanylmethyl[1,4]naphthoquinones and their activity against the human malaria parasite Plasmodium falciparum (3D7). European Journal of Medicinal Chemistry, v. 59, p. 48-53, 2013. Citações:81|84
50. FERREIRA, V. F. ; da Rocha, D. R. ; da Silva, F. C. ; Ferreira, P. G. ; BOECHAT, N. A. ; Magalhaes, J. L. . Novel 1H-1,2,3-, 2H-1,2,3-, 1H-1,2,4- and 4H-1,2,4-triazole derivatives: a patent review (2008-2011). Expert Opinion on Therapeutic Patents, v. 23, p. 319-331, 2013. Citações:63|71
51. Gomes, A. T. P. C. ; Martins, P. R. C. ; da Rocha, D. R. ; Neves, M. G. P. M. S. ; Ferreira, Vitor F. ; Silva, A. M. S. ; Cavaleiro, J. A. S. ; da Silva, F. C. . Consecutive Tandem Cycloaddition between Nitriles and Azides; Synthesis of 5-Amino-1H-[1,2,3]-triazoles. Synlett (Stuttgart), v. 24, p. 41-44, 2013. Citações:16|18
52. SCHUCK, DESIREE C ; FERREIRA, SABRINA B ; CRUZ, LAURA N ; DA ROCHA, DAVID R ; MORAES, MIRIAM ; NAKABASHI, MYNA ; ROSENTHAL, PHILIP J ; FERREIRA, VITOR F ; GARCIA, CELIA RS . Biological evaluation of hydroxynaphthoquinones as anti-malarials. Malaria Journal (Online), v. 12, p. 234, 2013. Citações:42|48
53. Costa, E. C. B. ; Amorim, R. ; da Silva, F. C. ; da Rocha, D. R. ; Papa, M. P. ; Arruda, L. B. ; Mohana-Borges, R. ; FERREIRA, V. F. ; Tanuri, A. ; Costa, L. J. ; FERREIRA, S. B. . Synthetic 1,4-Pyran Naphthoquinones Are Potent Inhibitors of Dengue Virus Replication. Plos One, v. 8, p. e82504, 2013. Citações:31|31
54. Gonzaga, D. T. G. ; da Rocha, D. R. ; da Silva, F. C. ; Ferreira, Vitor F. . Recent Advances in the Synthesis of New Antimycobacterial Agents Based on the 1H-1,2,3-Triazoles. CURRENT TOPICS IN MEDICINAL CHEMISTRY, v. 13, p. 2850-2865, 2013. Citações:42|41
55. de Pascual, R. ; Colmena. I. ; de los Rios, C. ; Rosa, J. M. ; Correa-Leite, P. E. ; ARAUJO, K. G. L. ; FERREIRA, V. F. ; da Rocha, David R. ; Gonzaga, D. T. G. ; García, A. G. ; SANTOS, W. C. ; Gandía, L. . Augmentation of catecholamine release elicited by an Eugenia punicifolia extract in chromaffin cells. Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy, v. 22, p. 1-12, 2012. Citações:4|3
56. da Silva, F. C. ; JORDAO, A. K. ; da Rocha, David R. ; FERREIRA, S. B. ; Cunha, A. C. ; FERREIRA, V. F. . Recent Advances on the Synthesis of Heterocycles from Diazo Compounds. CURRENT ORGANIC CHEMISTRY, v. 16, p. 224-251, 2012. Citações:26|30
57. da Rocha, David R.; Santos, Wilson C. ; Lima, Emerson S. ; Ferreira, Vitor F. . Synthesis of 1,2,3-Triazole Glycoconjugates as Inhibitors of ¿-Glucosidases. Carbohydrate Research (Chicago, Ill.. Print), v. 350, p. 14-19, 2012. Citações:44|46
58. da Silva, F. C. ; FERREIRA, S. B. ; da Rocha, David R. ; FERREIRA, V. F. . Chagas Disease: Challenges in Developing New Trypanocidal Lead Compounds. REVISTA VIRTUAL DE QUÍMICA, v. 4, p. 46-72, 2012. Citações:10
59. Rodrigues da Rocha, David; Gusmão de Souza, Ana Carolina ; Camargos Resende, Jackson A. L. ; da Costa Santos, Wilson ; Alves dos Santos, Evelyne ; Pessoa, Cláudia ; Odorico de Moraes, Manoel ; Costa-Lotufo, Letícia V. ; Carvalho Montenegro, Raquel ; Ferreira, Vitor F. . Synthesis of new 9-hydroxy-? and 7-hydroxy-?-pyran naphthoquinones and cytotoxicity against cancer cell lines. Organic & Biomolecular Chemistry, v. 9, p. 4315-4322, 2011. Citações:63|62
60. FERREIRA, S. B. ; da Rocha, David R. ; CARNEIRO, J. W. M. ; SANTOS, W. C. ; FERREIRA, V. F. . A New Method to Prepare 3-Alkyl-2-hydroxy-1,4-naphthoquinones. Synthesis of Lapachol and Phthiocol. Synlett (Stuttgart), v. 11, p. 1551-1554, 2011. Citações:29|27
61. FERREIRA, V. F. ; ROCHA, D. R. ; da Silva, F. C. . Potencialidades e oportunidades na química da sacarose e outros açúcares. QUIMICA NOVA, v. 32, p. 623-638, 2009. Citações:44|45
62. ROCHA, D. R.. Advances in total synthesis: A new approach to the synthesis of pteridic acids A and B. Revista Virtual de Química, v. 1, p. 182-185, 2009.
63. JORDAO, A. K. ; da Rocha, David R. ; da Silva, F. C. ; RIANELLI, R. S. ; FERREIRA, S. B. . The use of sodium dichloroisocyanurate (NaDCC) in the treatment of the dimethyl sulfide, a by-product of Swern reaction. International Journal of Wasterwater Treatment & Green Chemistry, v. 1, p. 51-54, 2009.
64. Ferreira, Vitor F. ; da Rocha, D. R. ; Lima Araujo, Katia G. ; Santos, Wilson C. . Advances in Drug Discovery to Assess Cholinergic Neurotransmission: A Systematic Review. Current Drug Discovery Technologies, v. 5, p. 236-249, 2008. Citações:4
65. da Rocha, David R.; Ferreira, Vitor F. ; Garcez-do-Carmo, Lucia ; Santos, Wilson C. . Design and Synthesis of Carbohydrate Derivatives for Antagonistic Activity at Muscarinic Receptor. Letters in Drug Design & Discovery, v. 5, p. 236-242, 2008. Citações:3|2
66. da Rocha, D. R.; FERREIRA, V. F. ; SANTOS, W. C. . Aspectos da Síntese Orgânica no Desenvolvimento de Métodos e de Moléculas Biologicamente Ativas. Revista Processos Químicos, v. 2, p. 9-22, 2008.
67. da Rocha, D. R.. Oxalyl Chloride: A Versatile Reagent in Organic Synthesis. Synlett (Stuttgart), v. 7, p. 1172-1173, 2007. Citações:4|5
68. da Rocha, D. R.. Phosphomolybdic Acid (PMA). Research Journal of Chemistry and Environment, v. 11, p. 102-103, 2007.
2. G. C. DE MORAES, LEONARDO ; B. GUIDINELE, MARIA CRISTINA ; F. FERREIRA, VITOR ; R. DA ROCHA, DAVID . One-Pot Sodium Azide-Free Synthesis of Aryl Azides from Anilines. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v. 36, p. e-20250002, 2025.
3. C. THURLER-JÚNIOR, JULIO ; S. MOREIRA, CAROLINE ; C. CASTIGLIONE, RAQUEL ; L. SIMÕES, RAFAEL ; G. G. RANDO, DANIELA ; F. T. R. MARTINS, FELIPE ; M. COGO, RAMON ; C. B. RIBEIRO, RUAN ; F. FERREIRA, VITOR ; D. B. PASCOAL, VINICIUS ; C. R. F. PASCOAL, AISLAN ; R. DA ROCHA, DAVID . Antiproliferative Activity of New Bis-Thionaphthoquinones in Cervical Cancer. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v. 36, p. e-20240207, 2025.
4. CESAR CIRNE-SANTOS, CLAUDIO ; GOMES GONZAGA, DANIEL TADEU ; OLIVEIRA DE RESENDE, GABRIEL ; GONÇALVES, MARIANA DE CASTRO ; ANDRADE, AYMEE DA SILVA ; FURTADO PACHECO, PAULO ANASTÁCIO ; DOS SANTOS-RODRIGUES, ALEXANDRE ; RABELO, VITOR WON-HELD ; ABREU, PAULA ALVAREZ ; FARIA, ROBSON XAVIER ; DA ROCHA, DAVID RODRIGUES ; DA SILVA, FERNANDO DE CARVALHO ; FERREIRA, VITOR FRANCISCO ; DE SOUZA BARROS, CAROLINE ; NUNES DE PALMER PAIXÃO, IZABEL CHRISTINA . PAV-05 Naphthoquinone Potently Inhibit Zika Virus Replication in Infected Cells. CURRENT TOPICS IN MEDICINAL CHEMISTRY, v. 25, p. 1733-1747, 2025.
5. GUERRA, FABIANA SÉLOS ; FREITAS, ROSANA HELENA COIMBRA NOGUEIRA DE ; MOLDOVAN, FLORINA ; ROCHA, DAVID RODRIGUES DA ; CARVALHO, RENATO SAMPAIO ; FERNANDES, PATRICIA DIAS . Design, Synthesis, and Bioactivity Assessment of Modified Vemurafenib Analog. PHARMACEUTICALS, v. 18, p. 1161, 2025.
6. SANTOS, THAÍS BARRETO ; DE SOUZA CRUZ LOPES CANUTO, ALEX ; MEIRA, JOÃO FRANCISCO BLAUDT VIRGILIO DE CARVALHO ; SANTOS-DINIZ, ANA CAROLINE ; RIBEIRO, RAFAELLA MACHADO DE ASSIS CABRAL ; PASCHOAL, CAROLINE REIS SANTIAGO ; RABELO, VITOR WON-HELD ; ABREU, PAULA ALVAREZ ; FERREIRA, VITOR FRANCISCO ; DA ROCHA, DAVID RODRIGUES ; ROBBS, BRUNO KAUFMANN . Mechanistic Insights into the Anticancer Action of Novel 2-Hydroxy-1,4-naphthoquinone Thiol Derivatives. ACS Omega, v. 10, p. 41975-41992, 2025. Citações:1|2
7. DE MORAES, LEONARDO GOMES CAVALIERI ; SANTOS, THAÍS BARRETO ; DA ROCHA, DAVID RODRIGUES . Molecular Hybridization of Naphthoquinones and Thiazoles: A Promising Strategy for Anticancer Drug Discovery. PHARMACEUTICALS, v. 18, p. 1887, 2025. Citações:1|2
8. G. C. DE MORAES, LEONARDO ; R. DA ROCHA, DAVID . Strategies for the Synthesis of Monohalogenated Analogues of Juglone: Unlocking the Potential of Regiospecific Synthesis Methodologies. REVISTA VIRTUAL DE QUÍMICA, v. 16, p. 127-137, 2024.
9. SILVA, STÉPHANE DA ; SILVA, EDUARDO MOREIRA DA ; CARVALHO, EDUARDA LIMA MUNIZ DE ; MOREIRA, CAROLINE DOS SANTOS ; DA ROCHA, DAVID RODRIGUES ; TURBINO, MIRIAM LACALLE ; PORTELA, MARISTELA BARBOSA ; AMARAL, CRISTIANE MARIOTE . Effect of dentin pretreatment with dialdehyde carboxymethyl cellulose on dentin properties and long-term adhesion. INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES, v. 120, p. 103296, 2023. Citações:4|4
10. PACHECO, PAULO ANASTÁCIO FURTADO ; GONZAGA, DANIEL TADEU GOMES ; VON RANKE, NATALIA LIDMAR ; RODRIGUES, CARLOS RANGEL ; DA ROCHA, DAVID RODRIGUES ; DA SILVA, FERNANDO DE CARVALHO ; FERREIRA, VITOR FRANCISCO ; FARIA, ROBSON XAVIER . Synthesis, Biological Evaluation and Molecular Modeling Studies of Naphthoquinone Sulfonamides and Sulfonate Ester Derivatives as P2X7 Inhibitors. MOLECULES, v. 28, p. 590, 2023. Citações:2|2
11. PACHECO, PAULO ANASTÁCIO FURTADO ; FARIA, JULIANA VIEIRA ; SILVA, ANA CLÁUDIA ; VON RANKE, NATALIA LIDMAR ; SILVA, ROBSON COUTINHO ; RODRIGUES, CARLOS RANGEL ; DA ROCHA, DAVID RODRIGUES ; FARIA, ROBSON XAVIER . In silico and pharmacological study of N,S-acetal juglone derivatives as inhibitors of the P2X7 receptor-promoted in vitro and in vivo inflammatory response. BIOMEDICINE & PHARMACOTHERAPY, v. 162, p. 114608, 2023. Citações:2|3
12. SANTOS, THAÍS BARRETO ; DE MORAES, LEONARDO GOMES CAVALIERI ; PACHECO, PAULO ANASTÁCIO FURTADO ; DOS SANTOS, DOUGLAS GALDINO ; RIBEIRO, RAFAELLA MACHADO DE ASSIS CABRAL ; MOREIRA, CAROLINE DOS SANTOS ; DA ROCHA, DAVID RODRIGUES . Naphthoquinones as a Promising Class of Compounds for Facing the Challenge of Parkinson’s Disease. PHARMACEUTICALS, v. 16, p. 1577, 2023. Citações:9|6
13. PACHECO, PAULO ; GONZAGA, DANIEL ; CIRNE-SANTOS, CLÁUDIO ; BARROS, CAROLINE ; GOMES, MAX ; GOMES, RAFAELA ; GONÇALVES, MARIANA ; FERREIRA, VITOR ; RABELO, VITOR ; ABREU, PAULA ; FARIA, ROBSON ; DE RESENDE, GABRIEL ; Da Rocha, David ; PAIXÃO, IZABEL ; DA SILVA, FERNANDO . Synthesis and Anti-Chikungunya Virus (CHIKV) Activity of Novel 1,4-Naphthoquinone Sulfonamide and Sulfonate Ester Derivatives. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v. 33, p. 556-569, 2022. Citações:11|11
14. GUILHON'SIMPLICIO, FERNANDA ; SERRÃO, CARLOS KLINGER RODRIGUES ; PINTO, ANA CRISTINA DA SILVA ; PACHECO, PAULO ANASTÁCIO FURTADO ; FARIA, ROBSON XAVIER ; ROCHA, DAVID RODRIGUES ; FERREIRA, VITOR FRANCISCO ; PEREIRA'JUNIOR, RAIMUNDO CARLOS ; MATHEEUSSEN, AN ; BAÁN, ADRIENN ; KIEKENS, FILIP ; MENESES PEREIRA, MARIA ; LIMA, EMERSON SILVA ; WINTER, HANS DE ; COS, PAUL . Semisynthetic triterpenes led to the generation of selective antitrypanosomal lead compounds. Chemical Biology & Drug Design, v. 99, p. 868-883, 2022. Citações:3|3
15. DE SOUSA PORTILHO, ADRHYANN JULLYANNE ; DA SILVA, EMERSON LUCENA ; BEZERRA, EMANUEL CINTRA AUSTREGÉSILO ; MORAES REGO GOMES, CARINNE BORGES DE SOUZA ; FERREIRA, VITOR ; DE MORAES, MARIA ELISABETE AMARAL ; DA ROCHA, DAVID RODRIGUES ; BURBANO, ROMMEL MÁRIO RODRIGUEZ ; MOREIRA-NUNES, CAROLINE AQUINO ; MONTENEGRO, RAQUEL CARVALHO . 1,4-Naphthoquinone (CNN1) Induces Apoptosis through DNA Damage and Promotes Upregulation of H2AFX in Leukemia Multidrug Resistant Cell Line. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, p. 8105, 2022. Citações:15|13
16. DOS SANTOS, JULIANA P. S. ; RIBEIRO, RUAN CARLOS B. ; FARIA, JULIANA V. ; BELLO, MURILO L. ; LIMA, CAROLINA G. S. ; PAULI, FERNANDA P. ; BORGES, AMANDA A. ; ROCHA, DAVID R. ; MORAES, MATHEUS G. ; FOREZI, LUANA S. M. ; Ferreira, Vitor F. ; FARIA, ROBSON X. ; DA SILVA, FERNANDO DE C. . Synthesis, biological evaluation and molecular modeling studies of novel 1,2,3-triazole-linked menadione-furan derivatives as P2X7 inhibitors. Journal of Bioenergetics and Biomembranes, v. 54, p. 227-239, 2022. Citações:10|10
17. DA SILVA, EMERSON LUCENA ; MESQUITA, FELIPE PANTOJA ; DE FARIAS RAMOS, INGRYD NAYARA ; DE SOUZA MORAES REGO GOMES, CARINNE BORGES ; DOS SANTOS MOREIRA, CAROLINE ; FERREIRA, VÍTOR FRANCISCO ; DA ROCHA, DAVID RODRIGUES ; DE OLIVEIRA BAHIA, MARCELO ; MOREIRA-NUNES, CAROLINE AQUINO ; DE SOUZA, CAROLINA ROSAL TEIXEIRA ; BURBANO, ROMMEL MARIO RODRIGUES ; MONTENEGRO, RAQUEL CARVALHO . Antitumoral effect of novel synthetic 8-hydroxy-2-((4-nitrophenyl)thio)naphthalene-1,4-dione (CNN16) via ROS-mediated DNA damage, apoptosis and anti-migratory effect in colon cancer cell line. TOXICOLOGY AND APPLIED PHARMACOLOGY, v. 456, p. 116256, 2022. Citações:8|8
18. DA SILVA MAGALHÃES FOREZI, LUANA ; GARCIA FERREIRA, PATRÍCIA ; Rodrigues da Rocha, David ; de Carvalho da Silva, Fernando ; FRANCISCO FERREIRA, VITOR . There is Chemistry Here: Supermarket. Part III: Carbohydrates. REVISTA VIRTUAL DE QUÍMICA, v. 14, p. 745-766, 2022.
19. LARA, LEONARDO S. ; LECHUGA, GUILHERME C. ; MOREIRA, CAROLINE DOS S. ; SANTOS, THAÍS B. ; Ferreira, Vitor F. ; da Rocha, David R.; PEREIRA, MIRIAN C. S. . Optimization of 1,4-Naphthoquinone Hit Compound: A Computational, Phenotypic, and In Vivo Screening against Trypanosoma cruzi. MOLECULES, v. 26, p. 423, 2021. Citações:15|14
20. FREITAS, ROSANA HELENA C. N. ; Rodrigues da Rocha, David . 4-(Dimethylamino)pyridine as Multivalent Catalyst in Organic Synthesis. AUSTRALIAN JOURNAL OF CHEMISTRY, v. 74, p. 364-366, 2021. Citações:2|2
21. Ferreira, Vitor F. ; DE CARVALHO, ALCIONE S. ; da Rocha, David R. . Strategies for the Synthesis of Mono- and Bis-Thionaphthoquinones. CURRENT ORGANIC SYNTHESIS, v. 18, p. 535-546, 2021. Citações:2|2
22. DE FREITAS, PAULA PRISCILLA ; RIBEIRO, RUAN CARLOS BUSQUET ; DOS SANTOS GUIMARÃES, ISABELLA ; MOREIRA, CAROLINE S. ; da Rocha, D. R. ; de Carvalho da Silva, Fernando ; FERREIRA, V. F. ; GIMBA, ETEL RODRIGUES PEREIRA . (3,3?-Methylene)bis-2-hydroxy-1,4-naphthoquinones induce cytotoxicity against DU145 and PC3 cancer cells by inhibiting cell viability and promoting cell cycle arrest. MOLECULAR BIOLOGY REPORTS, v. 48, p. 3253-3263, 2021. Citações:5|5
23. Moreira, C. S. ; SANTOS, T. B. ; FREITAS, ROSANA HELENA C. N. ; PACHECO, P. A. F. ; DA ROCHA, D.R. . Juglone: a versatile natural platform for obtaining new bioactive compounds. CURRENT TOPICS IN MEDICINAL CHEMISTRY, v. 21, p. 2018-2045, 2021. Citações:23|32
24. DE S. PORTILHO, ADRHYANN J. ; B. S. M. R. GOMES, CARINNE ; MOREIRA, CAROLINE S. ; DA S. M. FOREZI, LUANA ; CORDEIRO, PÂMELLA S. ; DO NASCIMENTO, VANESSA ; DANIEL, JULIO P. ; VASCONCELLOS, MARNE C. ; E. A. DE MORAES, MARIA ; DE F. A. MOREIRA-NUNES, CAROLINE ; Ferreira, Vitor F. ; MONTENEGRO, RAQUEL C. ; da Rocha, David R. . Synthesis, molecular docking, and biological activity of thioether derived from juglone in preclinical models of chronic myeloid leukemia. Computational Toxicology, v. 20, p. 100197, 2021. Citações:7|6
25. RIBEIRO, RUAN CARLOS ; DE FREITAS, PAULA ; MOREIRA, CAROLINE ; DE MORAES, LEONARDO ; DE MORAES, MATHEUS ; DA SILVA, FERNANDO ; Rocha, David ; GIMBA, ETEL ; FERREIRA, VITOR . A New Strategy for the Synthesis of Nonsymmetrical 3,3?-(Aryl/alkyl- methylene) bis-2-hydroxy-1,4-naphthoquinones and Their Cytotoxic Effects in PC3 Prostate Cancer Cells. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v. 31, p. 288-297, 2020. Citações:8|9
26. PACHECO, PAULO ANASTÁCIO FURTADO ; DE MENEZES RIBEIRO, THAIS ; DOS SANTOS GALVÃO, RAÍSSA MARIA ; DOS SANTOS, ELDIO GONÇALVES ; FARIA, ANA FLÁVIA MARTINS ; VON RANKE, NATALIA LIDMAR ; BELLO, MURILO LAMIM ; RODRIGUES, CARLOS RANGEL ; FERREIRA, VITOR FRANCISCO ; SOUZA, ANDRÉ LUIS ALMEIDA ; DE JESÚS HARDOIM, DAIANA ; DA SILVA CALABRESE, KATIA ; FARIA, ROBSON XAVIER ; DA ROCHA, DAVID RODRIGUES . Synthesis of new N,S-acetal analogs derived from juglone with cytotoxic activity against Trypanossoma cruzi. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, v. 52, p. 199-213, 2020. Citações:7|5
27. Rodrigues da Rocha, David; FRANCISCO FERREIRA, VITOR . Contributions of Chemistry to Low Contact Economy at the Time of COVID-19. REVISTA VIRTUAL DE QUÍMICA, v. 12, p. 1642-1652, 2020. Citações:2|2
28. Moreira, C. S. ; da Rocha, D. R. ; FARIAS, F. M. C. . Curso voluntário de atualização e aperfeiçoamento: Uma estratégia para o retorno dos jovens e adultos à sala de aula com ênfase no ensino CTS. Brazilian Journal of Development, v. 6, p. 100114-100125, 2020.
29. PACHECO, P.A.F. ; GALVÃO, R.M.S. ; FARIA, A.F.M. ; VON RANKE, N.L. ; RANGEL, M.S. ; RIBEIRO, T.M. ; BELLO, M.L. ; RODRIGUES, C.R. ; FERREIRA, V.F. ; DA ROCHA, D.R. ; FARIA, R.X. . 8-Hydroxy-2-(1H-1,2,3-triazol-1-yl)-1,4-naphtoquinone derivatives inhibited P2X7 Receptor-Induced dye uptake into murine Macrophages. BIOORGANIC & MEDICINAL CHEMISTRY, v. 27, p. 1449-1455, 2019. Citações:23|21
30. DE MELLO, MARCOS VINÍCIUS PALMEIRA ; CEBRIÁN-TORREJÓN, GERARDO ; PEREIRA, JONAS RAMOS ; DOS SANTOS MOREIRA, CAROLINE ; DE SOUZA MORAES REGO GOMES, CARINNE BORGES ; DA ROCHA, DAVID RODRIGUES ; DE SOUZA FAGUNDES, ELAINE MARIA; FERREIRA, GLAUCIO BRAGA ; LANZNASTER, MAURICIO . Evaluation of 5-hydroxy-1,4-naphthoquinone-cobalt(III) complexes for hypoxia-activated drug delivery. JOURNAL OF INORGANIC BIOCHEMISTRY, v. 199, p. 110756, 2019. Citações:10|12
31. MOREIRA, CAROLINE DOS S. ; NICOLETTI, CAROLINE D. ; PINHEIRO, DANIEL P. ; DE MORAES, LEONARDO G. C. ; FUTURO, DEBORA O. ; Ferreira, Vitor F. ; PESSOA, CLAUDIA DO Ó ; da Rocha, David R. . Synthesis of dehydro-?-lapachones, ?- and ?-lapachones, and screening against cancer cell lines. MEDICINAL CHEMISTRY RESEARCH, v. 28, p. 2109-2117, 2019. Citações:9|8
32. LARA, L.S. ; MOREIRA, C.S. ; CALVET, C.M. ; LECHUGA, G.C. ; SOUZA, R.S. ; BOURGUIGNON, S.C. ; FERREIRA, V.F. ; ROCHA, D. ; PEREIRA, M.C.S. . Efficacy of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinone derivatives against different Trypanosoma cruzi discrete type units: Identification of a promising hit compound. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 144, p. 572-581, 2018. Citações:41|40
33. NOVAIS, JULIANA S. ; MOREIRA, CAROLINE S. ; SILVA, ANA CAROLINA J.A. ; LOUREIRO, RAQUEL S. ; SÁ FIGUEIREDO, AGNES MARIE ; Ferreira, Vitor F. ; CASTRO, HELENA C. ; da Rocha, David R. . Antibacterial naphthoquinone derivatives targeting resistant strain Gram-negative bacteria in biofilms. MICROBIAL PATHOGENESIS, p. 105-114, 2018. Citações:49|52
34. WREDEN, ANNA BEATRIZ ; FERNANDES, LUIZA ; KELLEY, MIRIAN ; PEREIRA-NEVES, ANTÔNIO ; MOREIRA, CAROLINE S. ; da Rocha, David R. ; PALHANO, FERNANDO L . Selective and sensitive pull down of amyloid fibrils produced in vitro and in vivo by the use of pentameric-thiophene-coupled resins.. ACS Chemical Neuroscience, v. 9, p. 2807-2814, 2018. Citações:7|8
35. SODERO, A. C. R. ; ABRAHIM-VIEIRA, B. ; TORRES, P. H. M. ; PASCUTTI, P. G. ; GARCIA, CELIA RS ; FERREIRA, V. F. ; da Rocha, D. R. ; FERREIRA, S. B. ; Silva JR, F. P. . Insights into cytochrome bc1 complex binding mode of antimalarial 2-hydroxy-1,4-naphthoquinones through molecular modelling. Memórias do Instituto Oswaldo Cruz, v. 112, p. 299-308, 2017. Citações:15|18
36. CARDOSO, MARIANA F.C. ; Forezi, L. S. M. ; CAVALCANTE, V. G. S. ; JULIANI, C. S. R. ; Resende, J. A. L. C. ; da Rocha, D. R. ; da Silva, F. C. ; FERREIRA, V. F. . Synthesis of New Xanthenes Based on Lawsone and Coumarin via a Tandem Three-Component Reaction. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, p. 1926-1936, 2017. Citações:9|12
37. MOREIRA, C.S. ; SILVA, A.C.J.A. ; NOVAIS, J.S. ; SÁ FIGUEIREDO, A.M. ; FERREIRA, V.F. ; DA ROCHA, D.R. ; CASTRO, H.C. . Searching for a potential antibacterial lead structure against bacterial biofilms among new naphthoquinone compounds. Journal of Applied Microbiology (Print), v. 122, p. 651-662, 2017. Citações:33|33
38. CARDOSO, MARIANA ; GOMES, ANA ; MOREIRA, CAROLINE ; SIMÕES, MÁRIO ; NEVES, MARIA ; Da Rocha, David ; DA SILVA, FERNANDO ; MOREIRINHA, CATARINA ; ALMEIDA, ADELAIDE ; FERREIRA, VITOR ; CAVALEIRO, JOSÉ . Efficient Catalytic Oxidation of 3-Arylthio- and 3-Cyclohexylthio-lapachone Derivatives to New Sulfonyl Derivatives and Evaluation of Their Antibacterial Activities. Molecules (Basel. Online), v. 22, p. 302, 2017. Citações:10|10
39. LANZNASTER, MAURICIO ; DA SILVA, ALINE FARIAS MOREIRA ; VITAL, RENATA DE UZEDA ; MARTINS, DANIELA DE LUNA ; ROCHA, DAVID RODRIGUES ; FERREIRA, GLAUCIO BRAGA ; CAMARGOS-RESENDE, JACKSON A. L. . Investigation of cobalt(III)-tpa complexes as potential bioreductively activated carriers for naphthoquinone-based drugs. NEW JOURNAL OF CHEMISTRY, v. 41, p. 14960-14965, 2017. Citações:7|7
40. CARDOSO, MARIANA F.C. ; Salomão, K. ; BONBACA, A. C. ; da Rocha, D. R. ; da Silva, F. C. ; Cavaleiro, J. A. S. ; Castro, S. L. ; FERREIRA, V. F. . Synthesis and anti-Trypanosoma cruzi Activity of New 3¿Phenylthio-nor-?-lapachone Derivatives. Bioorganic & Medicinal Chemistry (Print), v. 23, p. 4763-4768, 2015. Citações:32|33
41. CAMPOS, VINICIUS R. ; CUNHA, ANNA C. ; SILVA, WANDERSON A. ; Ferreira, Vitor F. ; SANTOS DE SOUSA, CARLA ; FERNANDES, PATRÍCIA D. ; MOREIRA, VINÍCIUS N. ; da Rocha, David R. ; DIAS, FLAVIANA R. F. ; MONTENEGRO, RAQUEL C. ; DE SOUZA, MARIA C. B. V. ; BOECHAT, FERNANDA DA C. S. ; FRANCO, CAROLINE F. J. ; RESENDE, JACKSON A. L. C. . Synthesis of a new class of naphthoquinone glycoconjugates and evaluation of their potential as antitumoral agents. RSC Advances: an international journal to further the chemical sciences, v. 5, p. 96222-96229, 2015. Citações:24|24
42. FERREIRA, V. F. ; da Rocha, D. R. ; da Silva, F. C. . Green Chemistry, Sustainable Economy and Quality of Life. Revista Virtual de Química, v. 6, p. 85-111, 2014. Citações:16
43. da Rocha, D. R.; SILVA, K. M. ; SILVA, I. M. C. B. ; FERREIRA, V. F. ; FERREIRA, S. B. ; da Silva, F. C. . Synthesis of fused chromene-1,4-naphthoquinones via ring-closing metathesis and Knoevenagel-electrocyclization under acid catalysis and microwave irradiation. Tetrahedron (Oxford. Print), v. 70, p. 3266-3270, 2014. Citações:25|26
44. Rezende, C. M. ; da Silva, F. C. ; da Rocha, D. R. ; FERREIRA, V. F. . Piperylene Sulfone: A Smart Solvent. Revista Virtual de Química, v. 6, p. 131-141, 2014.
45. da Rocha, D. R.; Souza, A. M. T. ; de Souza, A. C. G. ; Castro, H. C. ; Rodrigues, C. R. ; Menna-Barreto, R. F. S. ; Castro, S. L. ; FERREIRA, V. F. . Effect of 9-hydroxy-a- and 7-hydroxy-pyran Naphthoquinones on Trypanosoma cruzi and Structure-activity Relationship Studies. Medicinal Chemistry, v. 10, p. 1-1, 2014. Citações:5|5
46. Pinto, E. G. ; SANTOS, I. O. ; Schmidt, T. J. ; Borborema, S. E. T. ; FERREIRA, V. F. ; da Rocha, D. R. ; Tempone, A. G. . Potential of 2-Hydroxy-3-Phenylsulfanylmethyl-[1,4]-Naphthoquinones against Leishmania (L.) infantum: Biological Activity and Structure-Activity Relationships. Plos One, v. 9, p. e105127, 2014. Citações:45|41
47. CARDOSO, MARIANA F.C. ; RODRIGUES, PATRÍCIA C. ; OLIVEIRA, MARIA EDUARDA I.M. ; GAMA, IVSON L. ; DA SILVA, ILLANA M.C.B. ; SANTOS, ISABELA O. ; ROCHA, DAVID R. ; PINHO, ROSA T. ; Ferreira, Vitor F. ; DE SOUZA, MARIA CECÍLIA B.V. ; DA SILVA, FERNANDO DE C. ; SILVA JUNIOR, FLORIANO PAES . Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines. European Journal of Medicinal Chemistry, v. 84, p. 708-717, 2014. Citações:53|54
48. Mariana F. C. Cardoso ; SILVA, I. M. C. B. ; SANTOS JUNIOR, H. M. ; da Rocha, David R. ; Ana Jérsia Araújo ; Pessoa, Cláudia ; Moraes, M. O. ; Costa-Lotufo, L. V. ; Fernando de Carvalho da Silva ; SANTOS, W. C. ; Vitor Francisco Ferreira . A new approach for the synthesis of 3-substituted cytotoxic nor-?-lapachones. Journal of the Brazilian Chemical Society (Impresso), v. 24, p. 12-16, 2013. Citações:21|18
49. Abhinay Sharma ; SANTOS, I. O. ; Pratibha Gaur ; Ferreira, Vitor F. ; Celia R.S Garcia ; da Rocha, David R. . Addition of thiols to o-quinone methide: New 2-hydroxy-3-phenylsulfanylmethyl[1,4]naphthoquinones and their activity against the human malaria parasite Plasmodium falciparum (3D7). European Journal of Medicinal Chemistry, v. 59, p. 48-53, 2013. Citações:81|84
50. FERREIRA, V. F. ; da Rocha, D. R. ; da Silva, F. C. ; Ferreira, P. G. ; BOECHAT, N. A. ; Magalhaes, J. L. . Novel 1H-1,2,3-, 2H-1,2,3-, 1H-1,2,4- and 4H-1,2,4-triazole derivatives: a patent review (2008-2011). Expert Opinion on Therapeutic Patents, v. 23, p. 319-331, 2013. Citações:63|71
51. Gomes, A. T. P. C. ; Martins, P. R. C. ; da Rocha, D. R. ; Neves, M. G. P. M. S. ; Ferreira, Vitor F. ; Silva, A. M. S. ; Cavaleiro, J. A. S. ; da Silva, F. C. . Consecutive Tandem Cycloaddition between Nitriles and Azides; Synthesis of 5-Amino-1H-[1,2,3]-triazoles. Synlett (Stuttgart), v. 24, p. 41-44, 2013. Citações:16|18
52. SCHUCK, DESIREE C ; FERREIRA, SABRINA B ; CRUZ, LAURA N ; DA ROCHA, DAVID R ; MORAES, MIRIAM ; NAKABASHI, MYNA ; ROSENTHAL, PHILIP J ; FERREIRA, VITOR F ; GARCIA, CELIA RS . Biological evaluation of hydroxynaphthoquinones as anti-malarials. Malaria Journal (Online), v. 12, p. 234, 2013. Citações:42|48
53. Costa, E. C. B. ; Amorim, R. ; da Silva, F. C. ; da Rocha, D. R. ; Papa, M. P. ; Arruda, L. B. ; Mohana-Borges, R. ; FERREIRA, V. F. ; Tanuri, A. ; Costa, L. J. ; FERREIRA, S. B. . Synthetic 1,4-Pyran Naphthoquinones Are Potent Inhibitors of Dengue Virus Replication. Plos One, v. 8, p. e82504, 2013. Citações:31|31
54. Gonzaga, D. T. G. ; da Rocha, D. R. ; da Silva, F. C. ; Ferreira, Vitor F. . Recent Advances in the Synthesis of New Antimycobacterial Agents Based on the 1H-1,2,3-Triazoles. CURRENT TOPICS IN MEDICINAL CHEMISTRY, v. 13, p. 2850-2865, 2013. Citações:42|41
55. de Pascual, R. ; Colmena. I. ; de los Rios, C. ; Rosa, J. M. ; Correa-Leite, P. E. ; ARAUJO, K. G. L. ; FERREIRA, V. F. ; da Rocha, David R. ; Gonzaga, D. T. G. ; García, A. G. ; SANTOS, W. C. ; Gandía, L. . Augmentation of catecholamine release elicited by an Eugenia punicifolia extract in chromaffin cells. Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy, v. 22, p. 1-12, 2012. Citações:4|3
56. da Silva, F. C. ; JORDAO, A. K. ; da Rocha, David R. ; FERREIRA, S. B. ; Cunha, A. C. ; FERREIRA, V. F. . Recent Advances on the Synthesis of Heterocycles from Diazo Compounds. CURRENT ORGANIC CHEMISTRY, v. 16, p. 224-251, 2012. Citações:26|30
57. da Rocha, David R.; Santos, Wilson C. ; Lima, Emerson S. ; Ferreira, Vitor F. . Synthesis of 1,2,3-Triazole Glycoconjugates as Inhibitors of ¿-Glucosidases. Carbohydrate Research (Chicago, Ill.. Print), v. 350, p. 14-19, 2012. Citações:44|46
58. da Silva, F. C. ; FERREIRA, S. B. ; da Rocha, David R. ; FERREIRA, V. F. . Chagas Disease: Challenges in Developing New Trypanocidal Lead Compounds. REVISTA VIRTUAL DE QUÍMICA, v. 4, p. 46-72, 2012. Citações:10
59. Rodrigues da Rocha, David; Gusmão de Souza, Ana Carolina ; Camargos Resende, Jackson A. L. ; da Costa Santos, Wilson ; Alves dos Santos, Evelyne ; Pessoa, Cláudia ; Odorico de Moraes, Manoel ; Costa-Lotufo, Letícia V. ; Carvalho Montenegro, Raquel ; Ferreira, Vitor F. . Synthesis of new 9-hydroxy-? and 7-hydroxy-?-pyran naphthoquinones and cytotoxicity against cancer cell lines. Organic & Biomolecular Chemistry, v. 9, p. 4315-4322, 2011. Citações:63|62
60. FERREIRA, S. B. ; da Rocha, David R. ; CARNEIRO, J. W. M. ; SANTOS, W. C. ; FERREIRA, V. F. . A New Method to Prepare 3-Alkyl-2-hydroxy-1,4-naphthoquinones. Synthesis of Lapachol and Phthiocol. Synlett (Stuttgart), v. 11, p. 1551-1554, 2011. Citações:29|27
61. FERREIRA, V. F. ; ROCHA, D. R. ; da Silva, F. C. . Potencialidades e oportunidades na química da sacarose e outros açúcares. QUIMICA NOVA, v. 32, p. 623-638, 2009. Citações:44|45
62. ROCHA, D. R.. Advances in total synthesis: A new approach to the synthesis of pteridic acids A and B. Revista Virtual de Química, v. 1, p. 182-185, 2009.
63. JORDAO, A. K. ; da Rocha, David R. ; da Silva, F. C. ; RIANELLI, R. S. ; FERREIRA, S. B. . The use of sodium dichloroisocyanurate (NaDCC) in the treatment of the dimethyl sulfide, a by-product of Swern reaction. International Journal of Wasterwater Treatment & Green Chemistry, v. 1, p. 51-54, 2009.
64. Ferreira, Vitor F. ; da Rocha, D. R. ; Lima Araujo, Katia G. ; Santos, Wilson C. . Advances in Drug Discovery to Assess Cholinergic Neurotransmission: A Systematic Review. Current Drug Discovery Technologies, v. 5, p. 236-249, 2008. Citações:4
65. da Rocha, David R.; Ferreira, Vitor F. ; Garcez-do-Carmo, Lucia ; Santos, Wilson C. . Design and Synthesis of Carbohydrate Derivatives for Antagonistic Activity at Muscarinic Receptor. Letters in Drug Design & Discovery, v. 5, p. 236-242, 2008. Citações:3|2
66. da Rocha, D. R.; FERREIRA, V. F. ; SANTOS, W. C. . Aspectos da Síntese Orgânica no Desenvolvimento de Métodos e de Moléculas Biologicamente Ativas. Revista Processos Químicos, v. 2, p. 9-22, 2008.
67. da Rocha, D. R.. Oxalyl Chloride: A Versatile Reagent in Organic Synthesis. Synlett (Stuttgart), v. 7, p. 1172-1173, 2007. Citações:4|5
68. da Rocha, D. R.. Phosphomolybdic Acid (PMA). Research Journal of Chemistry and Environment, v. 11, p. 102-103, 2007.
Ensino
| Sigla | Disciplina | Categoria |
|---|---|---|
| EGQ10208 | MECANISMOS DE REAÇÕES ORGÂNICAS | Obrigatória |
| EGQ00073 | QUÍMICA ORGÂNICA AVANÇADA II | Eletiva |
Orientações
Em Andamento
| # | Nível | Nome |
|---|---|---|
| 1 | doutorado | Leonardo Gomes Cavalieri de Moraes |
Concluídas
| # | Nível | Nome | Conclusão |
|---|---|---|---|
| 1 | mestrado | Carinne Borges de Souza Moraes Rego Gomes | 2018 |
| 2 | mestrado | Douglas Galdino dos Santos | 2023 |
| 3 | mestrado | Leonardo Gomes Cavalieri de Moraes | 2023 |
| 4 | mestrado | Vinícius Sodré Pereira | - |
| 5 | doutorado | Caroline dos Santos Moreira | 2022 |
| 6 | doutorado | Paulo Anastácio Furtado Pacheco | 2019 |
| 7 | doutorado | Thaís Barreto Santos | 2024 |
Coorientações
Em Andamento
| # | Nível | Nome | |||
|---|---|---|---|---|---|
| Nenhum registro encontrado. | |||||
Concluídas
| # | Nível | Nome | Conclusão |
|---|---|---|---|
| 1 | doutorado | Raísa da Rocha Reis | 2018 |
Supervisões (pós-doutorado)
Em Andamento
| # | Nome | Lattes |
|---|---|---|
| 1 | Thaís Barreto Santos |
Concluídas
| # | Nome | Lattes |
|---|---|---|
| 1 | Rosana Helena Coimbra Nogueira de Freitas |